This course examines how medicinal chemists design and synthesize drug candidates to meet FDA requirements of efficacy and safety, and how a testing strategy measures efficacy vs. toxicity comprising the therapeutic index. Topics include drug-receptor/enzyme binding, PK, ADME, patenting of IP, and the ethical aspects of pharmaceuticals.
Prerequisites: CHEM 361 or CHEM 370.
Outcomes: Students will be able explain the strategy of drug candidate analog design, synthesis, binding and inhibition constants, drug testing strategies, pharmacokinetics, structure-activity relationships (SAR), and the therapeutic index of drugs.
Prerequisites: CHEM 361 or CHEM 370.
Outcomes: Students will be able explain the strategy of drug candidate analog design, synthesis, binding and inhibition constants, drug testing strategies, pharmacokinetics, structure-activity relationships (SAR), and the therapeutic index of drugs.